Cellular architecture shapes the naïve T cell response

• DOI: 10.1126/science.adh8967
• Publication Date: 2024-06-06T17:59:38Z
• Authors: Benjamin D. Hale; Yannik Severin; Fabienne Graebnitz; Dominique Stark; Daniel Guignard; Julien Mena; Yasmin Festl; Sohyon Lee; Jacob Hanimann; Nathan S. Zangger; Michelle Meier; David Goslings; Olga Lamprecht; Beat M. Frey; Annette Oxenius; Berend Snijder
• Keywords: 0301 basic medicine; Nuclear Envelope; Receptors, Antigen, T-Cell; Cell Differentiation; CD8-Positive T-Lymphocytes; Lymphocyte Activation; Mice, Inbred C57BL; Mice; 03 medical and health sciences; Nuclear Receptor Subfamily 4, Group A, Member 1; Animals; Calcium; Immunologic Memory

After antigen stimulation, naïve T cells display reproducible population-level responses, which arise from individual pursuing specific differentiation trajectories. However, cell-intrinsic predeterminants controlling these single-cell decisions remain enigmatic. We found that the subcellular architectures of CD8 cells, defined by presence (T