Brain-muscle communication prevents muscle aging by maintaining daily physiology

• DOI: 10.1126/science.adj8533
• Publication Date: 2024-05-02T17:58:56Z
• Authors: Arun Kumar; Mireia Vaca-Dempere; Thomas Mortimer; Oleg Deryagin; Jacob G. Smith; Paul Petrus; Kevin B. Koronowski; Carolina M. Greco; Jessica Segalés; Eva Andrés; Vera Lukesova; Valentina M. Zinna; Patrick-Simon Welz; Antonio L. Serrano; Eusebio Perdiguero; Paolo Sassone-Corsi; Salvador Aznar Be...; Pura Muñoz-Cánoves
• Keywords: Homeostasis

A molecular clock network is crucial for daily physiology and maintaining organismal health. We examined the interactions importance of intratissue networks in muscle tissue maintenance. In arrhythmic mice showing premature aging, we created a basic module involving central peripheral (muscle) clock. Reconstituting brain-muscle sufficient to preserve fundamental homeostatic functions prevent aging. However, achieving whole requires contributions from other clocks. Mechanistically, acts as gatekeeper, selectively suppressing detrimental signals while integrating important functions. Our research reveals interplay between clocks function underscores impact eating patterns on these interactions.