T cell–derived interferon-γ programs stem cell death in immune-mediated intestinal damage

• DOI: 10.1126/sciimmunol.aay8556
• Publication Date: 2019-12-07T00:19:07Z
• Authors: S. Takashima; M. L. Martin; S. A. Jansen; Y. Fu; J. Bos; D. Chandra; M. H. O’Connor; A. M. Mertelsmann; P. Vinci; J. Kuttiyara; S. M. Devlin; S. Middendorp; M. Calafiore; A. Egorova; M. Kleppe; Y. Lo; N. F. Shroyer; E. H. Cheng; R. L. Levine; C. Liu; R. Kolesnick; C. A. Lindemans; A. M. Hanash
• Keywords: Cell Death; Research Support, Non-U.S. Gov't; Stem Cells; T-Lymphocytes; Immunology; T-Lymphocytes/immunology; Stem Cells/immunology; 3. Good health; Interferon-gamma; Mice; Research Support, N.I.H., Extramural; Interferon-gamma/immunology; Journal Article; Immunology and Allergy; Animals; Intestinal Mucosa; Intestinal Mucosa/cytology

T cell–derived interferon-γ can directly target intestinal stem cells to induce their apoptosis in a JAK/STAT-dependent manner (see the related Focus by Kretzschmar and Clevers ).