An IL-2 mutein engineered to promote expansion of regulatory T cells arrests ongoing autoimmunity in mice

• DOI: 10.1126/sciimmunol.aba5264
• Publication Date: 2020-08-14T23:13:53Z
• Authors: Liliane Khoryati; Minh Nguyet Pham; McKenna Sherve; Swarnima Kumari; Kevin Cook; Josh Pearson; Marika Bogdani; Daniel J. Campbell; Marc A. Gavin
• Keywords: Blood Glucose; Male; 0303 health sciences; Genetic Variation; Autoimmunity; Receptors, Fc; T-Lymphocytes, Regulatory; Recombinant Proteins; Mice, Inbred C57BL; 03 medical and health sciences; Diabetes Mellitus, Type 1; HEK293 Cells; Mice, Inbred NOD; Animals; Humans; Interleukin-2; Female; Mutant Proteins; Genetic Engineering; Pancreas

A CD25-dependent IL-2 mutein expanded regulatory T cells and controlled spontaneous diabetes in nonobese diabetic (NOD) mice.