Cholesterol 25-hydroxylase is a metabolic switch to constrain T cell–mediated inflammation in the skin

• DOI: 10.1126/sciimmunol.abb6444
• Publication Date: 2021-10-13T18:19:11Z
• Authors: H. Takahashi; H. Nomura; H. Iriki; A. Kubo; K. Isami; Y. Mikami; M. Mukai; T. Sasaki; J. Yamagami; J. Kudoh; H. Ito; A. Kamata; Y. Kurebayashi; H. Yoshida; A. Yoshimura; H. W. Sun; M. Suematsu; J. J. O’Shea; Y. Kanno; M. Amagai
• Keywords: Bystander effect

Interleukin-27 (IL-27) is an immunoregulatory cytokine whose essential function to limit immune responses. We found that the gene encoding cholesterol 25-hydroxylase (Ch25h) was induced in CD4