A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity

• DOI: 10.1126/sciimmunol.abf1152
• Publication Date: 2021-12-03T18:58:17Z
• Authors: Murillo Silva; Yu Kato; Mariane B. Melo; Ivy Phung; Brian L. Freeman; Zhongming Li; Kangsan Roh; Jan W. Van Wijnbe...; Hannah Watkins; Chiamaka A. Enemuo; Brittany L. Hartwell; Jason Y. H. Chang; Shuhao Xiao; Kristen A. Rodrigues; Kimberly M. Cirelli; Na Li; Sonya Haupt; Aereas Aung; Benjamin Cossette; Wuhbet Abraham; Swati Kataria; Raiza Bastidas; Jinal Bhiman; Caitlyn Linde; Nathaniel I. Bloom; Bettina Groschel; Erik Georgeson; Nicole Phelps; Ayush Thomas; Julia Bals; Diane G. Carnathan; Daniel Lingwood; Dennis R. Burton; Galit Alter; Timothy P. Padera; Angela M. Belcher; William R. Schief; Guido Silvestri; Ruth M. Ruprecht; Shane Crotty; Darrell J. Irvine
• Keywords: CD4-Positive T-Lymphocytes; 0301 basic medicine; B-Lymphocytes; Mice, Inbred BALB C; Toll-Like Receptors; Adaptive Immunity; Saponins; Macaca mulatta; Rats; 3. Good health; Mice, Inbred C57BL; Mice; 03 medical and health sciences; Adjuvants, Immunologic; Animals; Nanoparticles; Female; Lymph; Rats, Wistar

An adjuvant composed of saponin and a TLR4 agonist acts by enhancing lymph flow and antigen entry into lymph nodes.