Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared with adult and pediatric COVID-19

• DOI: 10.1126/sciimmunol.abf7570
• Publication Date: 2021-03-02T20:05:11Z
• Authors: Laura A. Vella; Josephine R. Giles; Amy E. Baxter; Derek A. Oldridge; Caroline Diorio; Leticia Kuri-Cerv...; Cécile Alanio; Maria Betina Pampena; Jennifer E. Wu; Zeyu Chen; Yinghui Jane Huang; Elizabeth M. Ande...; Sigrid Gouma; Kevin O. McNerney; Julie Chase; Chakkapong Burudp...; Jessica H. Lee; Sokratis A. Apost...; Alexander C. Huang; Divij Mathew; Oliva Kuthuru; Eileen C. Goodwin; Madison E. Weirick; Marcus J. Bolton; Claudia P. Arevalo; Andre Ramos; C. J. Jasen; Peyton E. Conrey; Samir Sayed; Heather M. Giannini; Kurt D’Andrea; ; Nuala J. Meyer; Edward M. Behrens; Hamid Bassiri; Scott E. Hensley; Sarah E. Henrickson; David T. Teachey; Michael R. Betts; E. John Wherry; Sharon Adamski; Zahidul Alam; Mary M. Addison; Katelyn T. Byrne; Aditi Chandra; Hélène C. Descamps; Nicholas Han; Yaroslav Kaminskiy; Shane C. Kammerman; Justin Kim; Allison R. Greenp...; Jacob T. Hamilton; Nune Markosyan; Julia Han Noll; Dalia K. Omran; Ajinkya Pattekar; Eric Perkey; Elizabeth M. Prager; Dana Pueschl; Austin Rennels; Jennifer B. Shah; Jake S. Shilan; Nils Wellhausen; Ashley N. Vanderbeck
• Keywords: Immunocompetence

Pediatric COVID-19 following SARS-CoV-2 infection is associated with fewer hospitalizations and often milder disease than in adults. A subset of children, however, present Multisystem Inflammatory Syndrome Children (MIS-C) that can lead to vascular complications shock, but rarely death. The immune features MIS-C compared pediatric or adult remain poorly understood. We analyzed peripheral blood responses hospitalized infected patients (pediatric COVID-19) MIS-C. had patterns T cell-biased lymphopenia cell activation similar severely ill adults, all spike-specific antibodies at admission. distinct feature was robust patrolling CX3CR1+ CD8+ cells correlated the use vasoactive medication. Finally, whereas acute respiratory distress syndrome (ARDS) sustained activation, displayed clinical improvement over time, concomitant decreasing activation. Thus, non-MIS-C versus illnesses are characterized by divergent signatures temporally from one another implicate presentation trajectory