Act1, a U-box E3 Ubiquitin Ligase for IL-17 Signaling

• DOI: 10.1126/scisignal.2000382
• Publication Date: 2009-10-21T20:53:18Z
• Authors: Caini Liu; Wen Qian; Youcun Qian; Natalia V. Giltiay; Yi Lu; Shadi Swaidani; Saurav Misra; Li Deng; Zhijian J. Chen; Xiaoxia Li
• Keywords: Ubiquitin-Protein Ligases

The adaptor protein Act1 functions as a ubiquitin ligase to mediate interleukin-17 receptor–dependent activation of nuclear factor-κB.