A Crucial Role for RACK1 in the Regulation of Glucose-Stimulated IRE1α Activation in Pancreatic β Cells

• DOI: 10.1126/scisignal.2000514
• Publication Date: 2010-01-26T22:34:41Z
• Authors: Yifu Qiu; Ting Mao; Yongliang Zhang; Mengle Shao; Jia You; Qiurong Ding; Yan Chen; Dongmei Wu; Dong Xie; Xu Lin; Xiang Gao; Randal J. Kaufman; Wenjun Li; Yong Liu
• Keywords: Male; 0301 basic medicine; Blotting, Western; Endoplasmic Reticulum; Cell Line; Neoplasm Proteins; Obesity, Morbid; Mice, Inbred C57BL; Islets of Langerhans; Mice; 03 medical and health sciences; Glucose; GTP-Binding Proteins; Cell Line, Tumor; Insulin-Secreting Cells; Multiprotein Complexes; Endoribonucleases; Animals; Humans; Insulin; Female; HT29 Cells

RACK1 dictates the response of intracellular stress sensor IRE1α to different extracellular stimuli.