The Mammalian MAPK/ERK Pathway Exhibits Properties of a Negative Feedback Amplifier

• DOI: 10.1126/scisignal.2001212
• Publication Date: 2010-12-21T20:59:23Z
• Authors: Oliver E. Sturm; Richard Orton; Joan Grindlay; Marc Birtwistle; Vladislav Vyshemi...; David Gilbert; Muffy Calder; Andrew Pitt; Boris Kholodenko; Walter Kolch
• Keywords: 0301 basic medicine; 570; Indoles; Immunoblotting; negative feedback amplifier; Mice; 03 medical and health sciences; Nitriles; Butadienes; Animals; Guanine Nucleotide Exchange Factors; Immunoprecipitation; Phosphorylation; Extracellular Signal-Regulated MAP Kinases; Feedback, Physiological; Cell Membrane; Models, Theoretical; Flow Cytometry; MAP Kinase Kinase Kinases; three-tiered kinase amplifier module; Kinetics; Electronic computers. Computer science; NIH 3T3 Cells; Quinazolines; Guanosine Triphosphate; mammalian MAPK/ERK pathway; Metabolic Networks and Pathways

Analysis of ERK pathway circuitry suggests appropriate targets for inhibition, providing a guide for drug development.