Wnt Signaling Regulates Hepatic Metabolism

• DOI: 10.1126/scisignal.2001249
• Publication Date: 2011-02-01T21:23:37Z
• Authors: Hongjun Liu; Maria M. Fergusson; J. Julie Wu; Ilsa I. Rovira; Jie Liu; Oksana Gavrilova; Teng Lu; Jianjun Bao; Donghe Han; Michael N. Sack; Toren Finkel
• Keywords: Mice, Knockout; 0301 basic medicine; Forkhead Box Protein O1; Blotting, Western; Forkhead Transcription Factors; Gene Expression Regulation, Enzymologic; Phosphoenolpyruvate Carboxylase; Mice; 03 medical and health sciences; Cytosol; Glucose; Liver; Cell Line, Tumor; Glucose-6-Phosphatase; Hepatocytes; Insulin Receptor Substrate Proteins; Animals; Protein Isoforms; RNA Interference; Obesity; Cells, Cultured; Protein Binding

Nutrient deprivation triggers β-catenin–dependent expression of genes encoding gluconeogenic enzymes.