Cyclic GMP and Protein Kinase G Control a Src-Containing Mechanosome in Osteoblasts

• DOI: 10.1126/scisignal.2001423
• Publication Date: 2010-12-21T20:59:23Z
• Authors: Hema Rangaswami; Raphaela Schwappa...; Nisha Marathe; Shunhui Zhuang; Darren E. Casteel; Bodo Haas; Yong Chen; Alexander Pfeifer; Hisashi Kato; Sanford Shattil; Gerry R. Boss; Renate B. Pilz
• Keywords: Mice, Knockout; 0301 basic medicine; Analysis of Variance; Integrin beta Chains; Osteoblasts; Immunoblotting; Fluorescent Antibody Technique; Cell Fractionation; Nitric Oxide; Mechanotransduction, Cellular; Models, Biological; Biomechanical Phenomena; Cell Line; Mice; 03 medical and health sciences; Bromodeoxyuridine; Cyclic GMP-Dependent Protein Kinases; Animals; Immunoprecipitation; Extracellular Signal-Regulated MAP Kinases; Cyclic GMP; Cell Proliferation

Drugs that activate protein kinase G could mimic the bone-building effects of mechanical stimulation.