Spatial Exclusivity Combined with Positive and Negative Selection of Phosphorylation Motifs Is the Basis for Context-Dependent Mitotic Signaling

• DOI: 10.1126/scisignal.2001796
• Publication Date: 2011-06-28T20:49:11Z
• Authors: Jes Alexander; Daniel Lim; Brian A. Joughin; Björn Hegemann; James R. A. Hutchins; Tobias Ehrenberger; Frank Ivins; Fabio Sessa; Otto Hudecz; Erich A. Nigg; Andrew M. Fry; Andrea Musacchio; P. Todd Stukenberg; Karl Mechtler; Jan-Michael Peters; Stephen J. Smerdon; Michael B. Yaffe
• Keywords: 0301 basic medicine; 571; Amino Acid Motifs; Mitosis; Cell Biology; Protein Serine-Threonine Kinases; Xenopus Proteins; Biochemistry; Evolution, Molecular; Xenopus laevis; 03 medical and health sciences; Peptide Library; Animals; Humans; Phosphorylation; Biologie; Molecular Biology; Signal Transduction

Mitotic kinases that localize to the same compartment show negative selectivity for residues in each other’s recognition motifs.