Systematic Phosphorylation Analysis of Human Mitotic Protein Complexes

• DOI: 10.1126/scisignal.2001993
• Publication Date: 2011-11-08T21:30:12Z
• Authors: Björn Hegemann; James R. A. Hutchins; Otto Hudecz; Maria Novatchkova; Jonathan Rameseder; Martina M. Sykora; Sihan Liu; Michael Mazanek; Péter Lénárt; Jean-Karim Hériché; Ina Poser; Norbert Kraut; Anthony A. Hyman; Michael B. Yaffe; Karl Mechtler; Jan-Michael Peters
• Keywords: 0301 basic medicine; 03 medical and health sciences; Humans; Mitosis; Cell Cycle Proteins; Phosphorylation; Protein Kinases; HeLa Cells

Analysis of the phosphorylation of mitotic protein complexes suggests that specific members of the complexes relay regulatory signals to these molecular machines.