Protein Kinase C η Is Required for T Cell Activation and Homeostatic Proliferation

• DOI: 10.1126/scisignal.2002058
• Publication Date: 2011-12-07T00:51:21Z
• Authors: Guo Fu; Jianfang Hu; Nathalie Niederbe...; Vasily Rybakin; Javier Casas; Pia P. Yachi; Stephanie Feldstein; Bo Ma; John A. H. Hoerter; Jeanette Ampudia; Stephanie Rigaud; Florence Lambolez; Amanda L. Gavin; Karsten Sauer; Hilde Cheroutre; Nicholas R. J. Ga...
• Keywords: CD4-Positive T-Lymphocytes; Mice, Knockout; Base Sequence; Immunological Synapses; CD4-CD8 Ratio; NF-kappa B; CD8-Positive T-Lymphocytes; Lymphocyte Activation; Isoenzymes; Mice, Inbred C57BL; Mice; 03 medical and health sciences; Phenotype; 0302 clinical medicine; Protein Kinase C-theta; Animals; Homeostasis; Calcium Signaling; RNA, Messenger; Immunologic Memory; Protein Kinase C; Cell Proliferation

Studies of knockout mice delineate specific and overlapping roles for different protein kinase C isoforms in T cell biology.