Neuronal Growth Cone Retraction Relies on Proneurotrophin Receptor Signaling Through Rac

• DOI: 10.1126/scisignal.2002060
• Publication Date: 2011-12-07T00:51:21Z
• Authors: Katrin Deinhardt; Taeho Kim; Daniel S. Spellman; Richard E. Mains; Betty A. Eipper; Thomas A. Neubert; Moses V. Chao; Barbara L. Hempstead
• Keywords: 570; 0303 health sciences; Growth Cones; Microfilament Proteins; Models, Neurological; Nerve Tissue Proteins; Receptors, Cell Surface; Receptor, Nerve Growth Factor; Actins; Cell Line; Rats; rac GTP-Binding Proteins; Mice; 03 medical and health sciences; 616; Animals; Guanine Nucleotide Exchange Factors; Humans; Carrier Proteins; Cells, Cultured; Signal Transduction

Whereas NGF promotes neurite outgrowth, the precursor form proNGF triggers neurite retraction.