A Dynamic Network Model of mTOR Signaling Reveals TSC-Independent mTORC2 Regulation

• DOI: 10.1126/scisignal.2002469
• Publication Date: 2012-03-27T22:15:23Z
• Authors: Piero Dalle Pezze; Annika G. Sonntag; Antje Thien; Mirja T. Prentzell; Markus Gödel; Sven Fischer; Elke Neumann-Haef...; Tobias B. Huber; Ralf Baumeister; Daryl P. Shanley; Kathrin Thedieck
• Keywords: Immunoblotting; Models, Biological; Cell Line; Phosphatidylinositol 3-Kinases; 03 medical and health sciences; Models; Animals; Humans; Immunoprecipitation; Insulin; Computer Simulation; Phosphorylation; Adaptor Proteins, Signal Transducing; 0303 health sciences; Ribosomal Protein S6 Kinases; TOR Serine-Threonine Kinases; Tumor Suppressor Proteins; Signal Transducing; Adaptor Proteins; Ribosomal Protein S6 Kinases, 70-kDa; Regulatory-Associated Protein of mTOR; Biological; 70-kDa; Rapamycin-Insensitive Companion of mTOR Protein; Gene Knockdown Techniques; Multiprotein Complexes; Carrier Proteins; Software; Transcription Factors; HeLa Cells; Protein Binding; Signal Transduction

Modeling and testing network structures reveal a distinct mechanism of mTORC2 activation by insulin.