p53 Functions in Endothelial Cells to Prevent Radiation-Induced Myocardial Injury in Mice

• DOI: 10.1126/scisignal.2002918
• Publication Date: 2012-07-24T20:04:31Z
• Authors: Chang-Lung Lee; Everett J. Moding; Kyle C. Cuneo; Yifan Li; Julie M. Sullivan; Lan Mao; Iman Washington; Laura B. Jeffords; Rafaela C. Rodrigues; Yan Ma; Shiva Das; Christopher D. Ko...; Yongbaek Kim; Howard A. Rockman; David G. Kirsch
• Keywords: 0301 basic medicine; Analysis of Variance; Integrases; Radiotherapy; Systole; Myocardium; Endothelial Cells; Cardiomegaly; Mice, Transgenic; Receptor, TIE-2; Capillary Permeability; Mice; Necrosis; Radiation Injuries, Experimental; 03 medical and health sciences; p21-Activated Kinases; Fluoroscopy; Animals; Tumor Suppressor Protein p53; Gene Deletion

Without the transcription factor p53 in cardiac endothelial cells, the heart is more susceptible to radiation-induced damage.