BRAF Inhibitors Induce Metastasis in RAS Mutant or Inhibitor-Resistant Melanoma Cells by Reactivating MEK and ERK Signaling

• DOI: 10.1126/scisignal.2004815
• Publication Date: 2014-03-25T20:53:22Z
• Authors: Berta Sanchez-Lao...; Amaya Viros; Maria Romina Girotti; Malin Pedersen; Grazia Saturno; Alfonso Zambon; Dan Niculescu-Duvaz; Samra Turajlic; Andrew Hayes; Martin Gore; James Larkin; Paul Lorigan; Martin Cook; Caroline Springer; Richard Marais
• Keywords: Proto-Oncogene Proteins B-raf; Indoles; Skin Neoplasms; MAP Kinase Signaling System; Blotting, Western; Mice, Nude; Enzyme-Linked Immunosorbent Assay; Statistics, Nonparametric; Proto-Oncogene Proteins p21(ras); Mice; 03 medical and health sciences; Animals; Humans; Dimethyl Sulfoxide; Neoplasm Invasiveness; Neoplasm Metastasis; Cell Shape; Melanoma; Animals; Blotting, Western; Cell Shape; Dimethyl Sulfoxide; Drug Resistance, Neoplasm; Enzyme-Linked Immunosorbent Assay; Humans; Indoles; Interleukin-8; MAP Kinase Signaling System; Melanoma; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins p21(ras); Skin Neoplasms; Statistics, Nonparametric; Sulfonamides; Biochemistry; Cell Biology; Molecular Biology; Medicine (all); Sulfonamides; 0303 health sciences; Interleukin-8; ResearchInstitutes_Networks_Beacons/mcrc; name=Manchester Cancer Research Centre; 3. Good health; Drug Resistance, Neoplasm

When therapy leads to cancer metastasis, knowing where else target in the pathway may be key successful treatment.