Semaphorin 3A activates the guanosine triphosphatase Rab5 to promote growth cone collapse and organize callosal axon projections

• DOI: 10.1126/scisignal.2005334
• Publication Date: 2014-08-26T23:33:26Z
• Authors: Kong-Yan Wu; Miao He; Qiong-Qiong Hou; Ai-Li Sheng; Lei Yuan; Fei Liu; Wen-Wen Liu; Guangpu Li; Xing-Yu Jiang; Zhen-Ge Luo
• Keywords: 0301 basic medicine; Microscopy, Confocal; Growth Cones; Microfluidics; Nerve Tissue Proteins; Receptors, Cell Surface; Axons; Mice, Mutant Strains; Neuropilin-1; Recombinant Proteins; Corpus Callosum; Rats; Enzyme Activation; Mice; 03 medical and health sciences; Electroporation; HEK293 Cells; Animals; Guanine Nucleotide Exchange Factors; Humans; Immunoprecipitation; RNA, Small Interfering

Endocytosis contributes to axon collapse mediated by a repulsive guidance cue in the developing brain.