Temporal and spatial regulation of epsin abundance and VEGFR3 signaling are required for lymphatic valve formation and function

• DOI: 10.1126/scisignal.2005413
• Publication Date: 2014-10-14T20:11:02Z
• Authors: Xiaolei Liu; Satish Pasula; Hoogeun Song; Kandice L. Tessneer; Yunzhou Dong; Scott Hahn; Tadayuki Yago; Megan L. Brophy; Baojun Chang; Xiaofeng Cai; Hao Wu; John McManus; Hirotake Ichise; Constantin Georgescu; Jonathan D. Wren; Courtney Griffin; Lijun Xia; R. Sathish Sriniv...; Hong Chen
• Keywords: Lymphatic Endothelium; Lymphangiogenesis; Lymphatic vessel

Proteins involved in endocytosis promote the internalization and degradation of VEGFR3, ensuring valve formation lymphatic vessels.