The kinase ALK stimulates the kinase ERK5 to promote the expression of the oncogene MYCN in neuroblastoma

• DOI: 10.1126/scisignal.2005470
• Publication Date: 2014-10-28T18:43:57Z
• Authors: Ganesh Umapathy; Abeer El Wakil; Barbara Witek; Louis Chesler; Laura Danielson; Xianming Deng; Nathanael S. Gray; Mikael Johansson; Samuel Kvarnbrink; Kristina Ruuth; Christina Schönherr; Ruth H. Palmer; Bengt Hallberg
• Keywords: Oncogene Proteins; N-Myc Proto-Oncogene Protein; 0303 health sciences; Green Fluorescent Proteins; Immunoblotting; Fluorescent Antibody Technique; Nuclear Proteins; Immunohistochemistry; Magnetic Resonance Imaging; PC12 Cells; 3. Good health; Gene Expression Regulation, Neoplastic; Neuroblastoma; 03 medical and health sciences; Cell Line, Tumor; Image Processing, Computer-Assisted; Animals; Humans; Immunoprecipitation; Anaplastic Lymphoma Kinase; RNA Interference; Mitogen-Activated Protein Kinase 7; DNA Primers

Targeting the kinase ERK5 may disrupt the activation of an oncogenic transcription factor in a subset of neuroblastoma patients.