Ferroportin and Iron Regulation in Breast Cancer Progression and Prognosis

• DOI: 10.1126/scisignal.3001127
• Publication Date: 2010-08-05T01:25:09Z
• Authors: Z. K. Pinnix; L. D. Miller; W. Wang; R. D'Agostino; T. Kute; M. C. Willingham; H. Hatcher; L. Tesfay; G. Sui; X. Di; S. V. Torti; F. M. Torti
• Keywords: 0301 basic medicine; Iron; Breast Neoplasms; Epithelial Cells; Prognosis; 3. Good health; Mice; 03 medical and health sciences; Treatment Outcome; Hepcidins; Disease Progression; Animals; Humans; Female; Breast; Cation Transport Proteins; Antimicrobial Cationic Peptides; Cell Proliferation

An iron efflux pump is a pivotal protein in breast cancer biology and a strong and independent predictor of breast cancer prognosis.