Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi

• DOI: 10.1126/scisignal.aab3729
• Publication Date: 2015-09-08T18:37:57Z
• Authors: Benjamin E. Housden; Alexander J. Valv...; Colleen Kelley; Richelle Sopko; Yanhui Hu; Charles Roesel; Shuailiang Lin; Michael Buckner; Rong Tao; Bahar Yilmazel; Stephanie E. Mohr; Brendan D. Manning; Norbert Perrimon
• Keywords: Gene knockout; Identification

Combining targeted CRISPR-mediated gene editing with an RNAi-mediated screen identifies candidate drug targets.