Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17

• DOI: 10.1126/scisignal.aac5356
• Publication Date: 2015-11-03T19:50:46Z
• Authors: Sathish K. Maney; David R. McIlwain; Robin Polz; Aleksandra A. Pan...; Balamurugan Sundaram; Dorit Wolff; Kazuhito Ohishi; Thorsten Maretzky; Matthew A. Brooke; Astrid Evers; Ananda A. Jaguva ...; Nima Aghaeepour; Jürgen Scheller; Carsten Münk; Dieter Häussinger; Tak W. Mak; Garry P. Nolan; David P. Kelsell; Carl P. Blobel; Karl S. Lang; Philipp A. Lang
• Keywords: 0301 basic medicine; Esophageal Neoplasms; Fibrosarcoma; Medizin; ADAM17 Protein; Receptors, Tumor Necrosis Factor; Neoplasm Proteins; Protein Structure, Tertiary; 3. Good health; ADAM Proteins; 03 medical and health sciences; Keratoderma, Palmoplantar; Cell Line, Tumor; Mutation; Humans; Genetic Predisposition to Disease

Without the N terminus, iRhom proteins cannot properly limit ADAM17 activity, resulting in impaired cancer cell death.