The protein arginine methyltransferase PRMT5 promotes D2-like dopamine receptor signaling

• DOI: 10.1126/scisignal.aad0872
• Publication Date: 2015-11-10T19:38:26Z
• Authors: Neah Likhite; Christopher A. Ja...; Mao-Shih Liang; Michelle C. Krzyz...; Pedro Lei; Jordan F. Wood; Barbara Birkaya; Kerry L. Michaels; Stelios T. Andreadis; Stewart D. Clark; Michael C. Yu; Denise M. Ferkey
• Keywords: Octanols; Protein-Arginine N-Methyltransferases; 0303 health sciences; Receptors, Dopamine D2; Dopamine; Amino Acid Motifs; Molecular Sequence Data; Computational Biology; Arginine; Methylation; Receptors, G-Protein-Coupled; Animals, Genetically Modified; 03 medical and health sciences; HEK293 Cells; Odorants; Animals; Humans; Amino Acid Sequence; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Conserved Sequence; Locomotion

Methylation of arginine residues in dopamine receptors in humans and worms promotes signaling and functional responses.