Cholesterol modulates Orai1 channel function

• DOI: 10.1126/scisignal.aad7808
• Publication Date: 2016-01-26T19:43:17Z
• Authors: Isabella Derler; Isaac Jardin; Peter B. Stathopulos; Martin Muik; Marc Fahrner; Vasilina Zayats; Saurabh K. Pandey; Michael Poteser; Barbara Lackner; Marketa Absolonova; Rainer Schindl; Klaus Groschner; Rüdiger Ettrich; Mitsu Ikura; Christoph Romanin
• Keywords: 0301 basic medicine; ORAI1 Protein; Cholesterol Oxidase; Circular Dichroism; Cell Membrane; Cell Line; Electrophysiological Phenomena; Protein Structure, Tertiary; 03 medical and health sciences; Cholesterol; HEK293 Cells; Mutation; Fluorescence Resonance Energy Transfer; Humans; Point Mutation; Biotinylation; Calcium; Calcium Channels; Mast Cells; Peptides; Histamine; Signal Transduction

Cholesterol suppresses the activity of a channel needed to refill intracellular calcium stores.