Conservation of protein abundance patterns reveals the regulatory architecture of the EGFR-MAPK pathway

• DOI: 10.1126/scisignal.aaf0891
• Publication Date: 2016-07-12T20:45:09Z
• Authors: Tujin Shi; Mario Niepel; Jason E. McDermott; Yuqian Gao; Carrie D. Nicora; William B. Chrisler; Lye M. Markillie; Vladislav A. Petyuk; Richard D. Smith; Karin D. Rodland; Peter K. Sorger; Wei-Jun Qian; H. Steven Wiley
• Keywords: ErbB Receptors; Mitogen-Activated Protein Kinase Kinases; 0301 basic medicine; 03 medical and health sciences; MAP Kinase Signaling System; Cell Line, Tumor; Humans; Breast Neoplasms; Female; Neoplasm Proteins

Abundance of most EGFR-MAPK pathway proteins is conserved across cell types, revealing adaptors as rate-limiting nodes.