Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling

• DOI: 10.1126/scisignal.aaf3273
• Publication Date: 2016-08-09T19:07:25Z
• Authors: Lomeli R. Carpio; Elizabeth W. Bradley; Meghan E. McGee-L...; Megan M. Weivoda; Daniel D. Poston; Amel Dudakovic; Ming Xu; Tamar Tchkonia; James L. Kirkland; Andre J. van Wijnen; Merry Jo Oursler; Jennifer J. Weste...
• Keywords: Mice, Knockout; 0301 basic medicine; Extracellular Matrix Proteins; Interleukin-6; Osteoclasts; Histone Deacetylases; Extracellular Matrix; 3. Good health; Autocrine Communication; Mice; 03 medical and health sciences; Chondrocytes; Pyrimidines; Osteogenesis; Nitriles; Animals; Pyrazoles; Janus Kinases; Signal Transduction

Histone deacetylase 3 prevents chondrocytes from producing inflammatory mediators that prevent bone development.