AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1

• DOI: 10.1126/scisignal.aaf7478
• Publication Date: 2017-01-31T19:30:33Z
• Authors: Traci L. Marin; Brendan Gongol; Fan Zhang; Marcy Martin; David A. Johnson; Han Xiao; Yinsheng Wang; Shankar Subramaniam; Shu Chien; John Y.-J. Shyy
• Keywords: DNA (Cytosine-5-)-Methyltransferase 1; 0301 basic medicine; Cells; 1.1 Normal biological development and functioning; Immunoblotting; AMP-Activated Protein Kinases; Promoter Regions; Mitochondrial Proteins; 03 medical and health sciences; Genetic; Underpinning research; Tandem Mass Spectrometry; Genetics; Uncoupling Protein 3; Humans; Uncoupling Protein 2; Phosphorylation; Promoter Regions, Genetic; Cells, Cultured; Histone Acetyltransferases; Cultured; Organelle Biogenesis; DNA Methylation; Chromatin Assembly and Disassembly; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Nucleosomes; DNA-Binding Proteins; Retinoblastoma-Binding Protein 7; Generic health relevance; Biochemistry and Cell Biology; Protein Binding; Transcription Factors

AMPK phosphorylates epigenetic factors to couple mitochondrial biogenesis and function with cellular energy needs.