Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non–small cell lung cancer

• DOI: 10.1126/scisignal.aaf8223
• Publication Date: 2017-01-10T19:30:24Z
• Authors: Cristina Gamell; Twishi Gulati; Yaara Levav-Cohen; Richard J. Young; Hongdo Do; Pat Pilling; Elena Takano; Neil Watkins; Stephen B. Fox; Prudence Russell; Doron Ginsberg; Brendon J. Monahan; Gavin Wright; Alex Dobrovic; Sue Haupt; Ben Solomon; Ygal Haupt
• Keywords: Mice, Knockout; 0301 basic medicine; 0303 health sciences; Lung Neoplasms; Nuclear Proteins; Cell Cycle Proteins; Kaplan-Meier Estimate; DNA Methylation; Fibroblasts; Embryo, Mammalian; 3. Good health; Gene Expression Regulation, Neoplastic; 03 medical and health sciences; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Animals; Humans; Cyclin-Dependent Kinase Inhibitor p19; Promoter Regions, Genetic; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p16; E2F1 Transcription Factor; Cyclin-Dependent Kinase Inhibitor p15; Protein Binding

E6AP exhibits tumor suppressor activity that may help stratify NSCLC patients.