Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non–small cell lung cancer
Mice, Knockout
0301 basic medicine
Lung Neoplasms
Nuclear Proteins
Cell Cycle Proteins
Kaplan-Meier Estimate
DNA Methylation
Fibroblasts
Embryo, Mammalian
3. Good health
Gene Expression Regulation, Neoplastic
03 medical and health sciences
Carcinoma, Non-Small-Cell Lung
Cell Line, Tumor
Animals
Humans
Cyclin-Dependent Kinase Inhibitor p19
Promoter Regions, Genetic
Cells, Cultured
Cyclin-Dependent Kinase Inhibitor p16
E2F1 Transcription Factor
Cyclin-Dependent Kinase Inhibitor p15
Protein Binding
DOI:
10.1126/scisignal.aaf8223
Publication Date:
2017-01-10T19:30:24Z
AUTHORS (17)
ABSTRACT
E6AP exhibits tumor suppressor activity that may help stratify NSCLC patients.
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CITATIONS (22)
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