Loss of SPDEF and gain of TGFBI activity after androgen deprivation therapy promote EMT and bone metastasis of prostate cancer

• DOI: 10.1126/scisignal.aam6826
• Publication Date: 2017-08-15T18:20:23Z
• Authors: Wei-Yu Chen; Yuan-Chin Tsai; Hsiu-Lien Yeh; Florent Suau; Kuo-Ching Jiang; Ai-Ning Shao; Jiaoti Huang; Yen-Nien Liu
• Keywords: Male; 0301 basic medicine; Extracellular Matrix Proteins; Epithelial-Mesenchymal Transition; Proto-Oncogene Proteins c-ets; Mice, Nude; Prostatic Neoplasms; Androgen Antagonists; Bone Neoplasms; Xenograft Model Antitumor Assays; 3. Good health; Gene Expression Regulation, Neoplastic; Mice; 03 medical and health sciences; Receptors, Androgen; Transforming Growth Factor beta; Tumor Cells, Cultured; Animals; Humans; Signal Transduction

Loss of a TGFβ signaling repressor by androgen deprivation therapy shows how a common treatment for primary prostate cancer may promote metastasis.