Inhibition of somatosensory mechanotransduction by annexin A6

• DOI: 10.1126/scisignal.aao2060
• Publication Date: 2018-06-19T18:15:35Z
• Authors: Ramin Raouf; Stéphane Lolignier; Jane E. Sexton; Queensta Millet; Sonia Santana-Varela; Anna Biller; Alice M. Fuller; Vanessa Pereira; Jyoti S. Choudhary; Mark O. Collins; Stephen E. Moss; Richard Lewis; Julie Tordo; Els Henckaerts; Michael Linden; John N. Wood
• Keywords: Male; 0301 basic medicine; 570; Cell biology; 1303 Biochemistry; Sensory Receptor Cells; Molecular biology; 610; Pain; Biochemistry; Mechanotransduction, Cellular; Ion Channels; 1307 Cell Biology; Mice; 03 medical and health sciences; Osteoarthritis; 1312 Molecular Biology; Animals; Biotinylation; [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]; Annexin A6; Cells, Cultured; Mice, Knockout; Arthritis, Experimental; Peptide Fragments; Mice, Inbred C57BL; [SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology; Conotoxins

The membrane-binding protein annexin A6 suppresses mechanically induced pain in a mouse model of osteoarthritis.