CARD9 mediates dendritic cell–induced development of Lyn deficiency–associated autoimmune and inflammatory diseases

• DOI: 10.1126/scisignal.aao3829
• Publication Date: 2019-10-08T23:45:11Z
• Authors: Jun Ma; Clare L. Abram; Yongmei Hu; Clifford A. Lowell
• Keywords: 0301 basic medicine; Knockout; Autoimmunity; Mice, Transgenic; Inbred C57BL; Autoimmune Disease; Oral and gastrointestinal; Transgenic; Mice; 03 medical and health sciences; 2.1 Biological and endogenous factors; Animals; Syk Kinase; Aetiology; Mice, Knockout; Animal; Arthritis; Inflammatory and immune system; Inflammatory Bowel Disease; Toll-Like Receptors; Dendritic Cells; Inflammatory Bowel Diseases; Interleukin-10; 3. Good health; CARD Signaling Adaptor Proteins; Mice, Inbred C57BL; Disease Models, Animal; Protein Kinase C-delta; src-Family Kinases; Disease Models; RNA Interference; Biochemistry and Cell Biology; Digestive Diseases; Signal Transduction

Without the kinase Lyn, the adaptor protein CARD9 amplifies cytokine production in autoimmune disease.