Dual phosphorylation of Ric-8A enhances its ability to mediate G protein α subunit folding and to stimulate guanine nucleotide exchange

• DOI: 10.1126/scisignal.aap8113
• Publication Date: 2018-05-29T18:15:41Z
• Authors: Makaía M. Papaser...; Hannah M. Stoveken; Lauren MacConnachie; Pui-Yee Chan; Meital Gabay; Dorothy Wong; Robert S. Freeman; Asim A. Beg; Gregory G. Tall
• Keywords: Threonine; Protein Folding; 0303 health sciences; Protein Conformation; Nuclear Proteins; Guanosine Diphosphate; GTP-Binding Protein alpha Subunits; Rats; 03 medical and health sciences; Guanosine 5'-O-(3-Thiotriphosphate); Serine; Animals; Guanine Nucleotide Exchange Factors; Humans; Amino Acid Sequence; Phosphorylation; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Signal Transduction

Phosphorylation of evolutionarily conserved sites enhances the function of the Gα subunit chaperone and regulator Ric-8A.