Lgl reduces endosomal vesicle acidification and Notch signaling by promoting the interaction between Vap33 and the V-ATPase complex

• DOI: 10.1126/scisignal.aar1976
• Publication Date: 2018-06-05T18:20:26Z
• Authors: Marta Portela; Liu Yang; Sayantanee Paul; Xia Li; Alexey Veraksa; Linda M. Parsons; Helena E. Richardson
• Keywords: 0301 basic medicine; Vacuolar Proton-Translocating ATPases; 0303 health sciences; Receptors, Notch; Tumor Suppressor Proteins; Cell Polarity; Membrane Proteins; Endosomes; Eye; Epithelium; 3. Good health; Biological sciences; 03 medical and health sciences; Drosophila melanogaster; FOS: Biological sciences; Biochemistry and cell biology; Vacuoles; Animals; Drosophila Proteins; Female; Carrier Proteins; Acids; Signal Transduction

Lgl reduces Notch activation by cooperating with Vap33 to inhibit the vacuolar ATPase, thereby reducing endosome acidification.