Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1

• DOI: 10.1126/scisignal.aau0597
• Publication Date: 2018-09-25T18:15:16Z
• Authors: Sam A. Jamieson; Zheng Ruan; Abigail E. Burgess; Jack R. Curry; Hamish D. McMillan; Jodi L. Brewster; Anita K. Dunbier; Alison D. Axtman; Natarajan Kannan; Peter D. Mace
• Keywords: 0303 health sciences; Ubiquitin-Protein Ligases; Intracellular Signaling Peptides and Proteins; Molecular Dynamics Simulation; Protein Serine-Threonine Kinases; Crystallography, X-Ray; Substrate Specificity; 03 medical and health sciences; Protein Domains; CCAAT-Enhancer-Binding Proteins; Humans; Fluorometry; Phosphorylation; Allosteric Site; Protein Binding

Allosteric regulation of the pseudokinase TRIB1 reveals therapeutic potential kinase inhibitors.