Induction of metabolic quiescence defines the transitional to follicular B cell switch

• DOI: 10.1126/scisignal.aaw5573
• Publication Date: 2019-10-22T23:24:11Z
• Authors: Jocelyn R. Farmer; Hugues Allard-Cha...; Na Sun; Maimuna Ahmad; Alice Bertocchi; Vinay S. Mahajan; Toby Aicher; Johan Arnold; Mark D. Benson; Jordan Morningstar; Sara Barmettler; Grace Yuen; Samuel J. H. Murphy; Jolan E. Walter; Musie Ghebremichael; Alex K. Shalek; Facundo Batista; Robert Gerszten; Shiv Pillai
• Keywords: 0301 basic medicine; 570; B-Lymphocytes; Class I Phosphatidylinositol 3-Kinases; 610; AMP-Activated Protein Kinases; Mechanistic Target of Rapamycin Complex 1; Ribonucleotides; Aminoimidazole Carboxamide; GPI-Linked Proteins; Pediatrics; Mice; 03 medical and health sciences; Medicine and Health Sciences; Animals; Humans; 5'-Nucleotidase

Extracellular adenosine salvage and AMPK activation are enhanced in a stage-specific manner during human B cell development.