Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival

• DOI: 10.1126/scisignal.aaw9315
• Publication Date: 2019-10-15T23:25:12Z
• Authors: Miho Watanabe; Jinwei Zhang; M. Shahid Mansuri; Jingjing Duan; Jason K. Karimy; Eric Delpire; Seth L. Alper; Richard P. Lifton; Atsuo Fukuda; Kristopher T. Kahle
• Keywords: Central Nervous System; Male; Mice, Knockout; Neurons; 570; Binding Sites; Mice, 129 Strain; Symporters; Gene Expression Regulation, Developmental; 3. Good health; Mice, Inbred C57BL; Animals, Newborn; Chlorides; K Cl- Cotransporters; Animals; Phosphorylation; Cells, Cultured; gamma-Aminobutyric Acid; Signal Transduction

Homozygous knockin mice reveal critical regulation of the neuronal channel KCC2 in synaptic development.