Engineering γδT cells limits tonic signaling associated with chimeric antigen receptors

• DOI: 10.1126/scisignal.aax1872
• Publication Date: 2019-09-10T23:15:12Z
• Authors: Jonathan Fisher; Roshan Sharma; Dilu Wisidagamage...; Marta Barisa; Marina Olle Hurtado; Pierre Abramowski; Lucy Porter; William Day; Roberto Borea; Sarah Inglott; John Anderson; Dana Pe’er
• Keywords: Cytotoxicity, Immunologic; 0301 basic medicine; Receptors, Chimeric Antigen; CD3 Complex; T-Lymphocytes; Receptors, Antigen, T-Cell, gamma-delta; Lymphocyte Activation; Immunotherapy, Adoptive; 03 medical and health sciences; HEK293 Cells; Cell Line, Tumor; Neoplasms; Humans; Genetic Engineering; Cells, Cultured; Signal Transduction

Changing the type of T cell used to generate CAR-T cells avoids the deleterious effects of antigen-independent signaling.