Glial IL-33 signaling through an ST2-to-CXCL12 pathway in the spinal cord contributes to morphine-induced hyperalgesia and tolerance

• DOI: 10.1126/scisignal.abe3773
• Publication Date: 2021-09-07T17:55:12Z
• Authors: Xue-Ming Hu; Wei Yang; Meng-Ting Zhang; Li-Xia Du; Jia-He Tian; Jian-Yu Zhu; Yu Chen; Feng Hai; Shen-Bin Liu; Qi-Liang Mao-Ying; Yu-Xia Chu; Hong Zhou; Yan-Qing Wang; Wen-Li Mi
• Keywords: Rats, Sprague-Dawley; 0301 basic medicine; 0303 health sciences; 03 medical and health sciences; Morphine; Spinal Cord; Hyperalgesia; Animals; Receptors, Interleukin-1; Interleukin-33; Rats; 3. Good health

Blocking opioid-induced chemokine release from astrocytes may improve long-term pain management.