The transcription factor XBP1 in dendritic cells promotes the T H 2 cell response in airway allergy

• DOI: 10.1126/scisignal.abm9454
• Publication Date: 2023-06-27T17:58:20Z
• Authors: Gui Yang; Xian-Hai Zeng; Xiao-Rui Geng; Jiang-Qi Liu; Li-Hua Mo; Xiang-Qian Luo; Hua-Zhen Liu; Yuan-Yi Zhang; Li-Teng Yang; Qin-Miao Huang; Xiao-Jun Xiao; Jie Liu; Ling-Zhi Xu; Da-Bo Liu; Xiao-Yu Liu; Zhi-Qiang Liu; Ping-Chang Yang
• Keywords: XBP1

Dendritic cells (DCs) that express T cell immunoglobulin domain molecule-4 (TIM4), a surface receptor for phosphatidylserine, induce helper 2 (T H 2) responses and allergic reactions. We elucidated the role of transcription factor X-box–binding protein-1 (XBP1) in induction response through its generating TIM4 + DCs. found XBP1 was required mRNA protein expression airway DCs to cytokine interleukin-2 (IL-2) this pathway on allergens PM2.5 Derf1. The IL-2–XBP1–TIM4 axis contributed Derf1/PM2.5-induced, aberrant vivo. An interaction between guanine nucleotide exchange Son sevenless-1 (SOS1) GTPase RAS promoted production Targeting XBP1-TIM4 prevented or alleviated experimental allergy. Together, these data suggest is by inducing development DCs, which depends IL-2–XBP1–SOS1 axis. This signaling provides potential therapeutic targets treatment cell–dependent inflammation diseases.