Yap and Taz promote osteogenesis and prevent chondrogenesis in neural crest cells in vitro and in vivo

• DOI: 10.1126/scisignal.abn9009
• Publication Date: 2022-10-25T17:58:10Z
• Authors: Xiaolei Zhao; Li Tang; Tram P. Le; Bao H. Nguyen; Wen Chen; Mingjie Zheng; Hiroyuki Yamaguchi; Brian Dawson; Shuangjie You; Idaliz M. Martine...; Shannon Erhardt; Jianxin Wang; Min Li; James F. Martin; Brendan H. Lee; Yoshihiro Komatsu; Jun Wang
• Keywords: Chondrogenesis; RUNX2; SOX9

Neural crest cells (NCCs) are multipotent stem that can differentiate into multiple cell types, including the osteoblasts and chondrocytes, constitute most of craniofacial skeleton. Here, we show through in vitro vivo studies transcriptional regulators Yap Taz have redundant functions as key determinants specification differentiation NCCs or chondrocytes. Primary cultured deficient