Pannexin-3 stabilizes the transcription factor Bcl6 in a channel-independent manner to protect against vascular oxidative stress

• DOI: 10.1126/scisignal.adg2622
• Publication Date: 2024-01-30T18:58:11Z
• Authors: Abigail G. Wolpe; Melissa A. Luse; Christopher Baryi...; Wyatt J. Schug; Jacob B. Wolpe; Scott R. Johnstone; Luke S. Dunaway; Zuzanna J. Juśkie...; Skylar A. Loeb; Henry R. Askew Page; Yen-Lin Chen; Vikram Sabapathy; Caitlin M. Pavelec; Brent Wakefield; Eugenia Cifuentes...; Mykhaylo V. Artam...; Avril V. Somlyo; Adam C. Straub; Rahul Sharma; Frank Beier; Eugene J. Barrett; Norbert Leitinger; Patrick J. Pagano; Swapnil K. Sonkusare; Stefanie Redemann; Linda Columbus; Silvia Penuela; Brant E. Isakson
• Keywords: NOX4; Endothelial Dysfunction

Targeted degradation regulates the activity of transcriptional repressor Bcl6 and its ability to suppress oxidative stress inflammation. Here, we report that abundance endothelial is determined by interaction with Golgi-localized pannexin 3 (Panx3) protects against vascular stress. Consistent data from obese, hypertensive humans, mice an cell-specific deficiency in