Identification of Therapeutic Targets for Quiescent, Chemotherapy-Resistant Human Leukemia Stem Cells

• DOI: 10.1126/scitranslmed.3000349
• Publication Date: 2010-02-03T23:17:32Z
• Authors: Yoriko Saito; Hiroshi Kitamura; Atsushi Hijikata; Mariko Tomizawa-M...; Satoshi Tanaka; Shinsuke Takagi; Naoyuki Uchida; Nahoko Suzuki; Akiko Sone; Yuho Najima; Hidetoshi Ozawa; Atsushi Wake; Shuichi Taniguchi; Leonard D. Shultz; Osamu Ohara; Fumihiko Ishikawa
• Keywords: 0301 basic medicine; Leukemia; Gene Expression Regulation, Leukemic; Cell Cycle; Receptors, IgG; Transplantation, Heterologous; Interleukin-2 Receptor alpha Subunit; Antineoplastic Agents; Cell Separation; Mice, SCID; Flow Cytometry; 3. Good health; Mice; 03 medical and health sciences; Drug Resistance, Neoplasm; Drug Design; Neoplastic Stem Cells; Animals; Humans; Cell Lineage; Bone Marrow Transplantation

CD32 and CD25, molecules specifically found in human leukemia stem cells, are promising targets for therapy.