The Fate and Toxicity of Raman-Active Silica-Gold Nanoparticles in Mice

• DOI: 10.1126/scitranslmed.3001963
• Publication Date: 2011-04-20T18:37:44Z
• Authors: Avnesh S. Thakor; Richard Luong; Ramasamy Paulmurugan; Frank I. Lin; Paul Kempen; Cristina Zavaleta; Pauline Chu; Tarik F. Massoud; Robert Sinclair; Sanjiv S. Gambhir
• Keywords: Male; Metal Nanoparticles; 02 engineering and technology; Silicon Dioxide; Spectrum Analysis, Raman; Polyethylene Glycols; 3. Good health; Mice; Animals; Female; Gold; 0210 nano-technology

Gold-core nanoparticles designed for imaging by Raman spectroscopy in patients are generally nontoxic mice, causing only temporary liver inflammation when given intravenously.