Cytosolic DNA Triggers Inflammasome Activation in Keratinocytes in Psoriatic Lesions

• DOI: 10.1126/scitranslmed.3002001
• Publication Date: 2011-05-11T19:00:33Z
• Authors: Yvonne Dombrowski; Mark Peric; Sarah Koglin; Claudia Kammerbauer; Christine Göß; David Anz; Maren Simanski; Regine Gläser; Jürgen Harder; Veit Hornung; Richard L. Gallo; Thomas Ruzicka; Robert Besch; Jürgen Schauber
• Keywords: Keratinocytes; Inflammasomes; Interleukin-1beta; 610; Nuclear Proteins; DNA; DNA-Binding Proteins; 03 medical and health sciences; Cytosol; 0302 clinical medicine; Cathelicidins; Humans; Psoriasis; Antimicrobial Cationic Peptides; Protein Binding

In psoriasis, cytosolic DNA in keratinocytes triggers maturation of the cytokine IL-1β via the AIM2 inflammasome.