Targeting Nrf2 Signaling Improves Bacterial Clearance by Alveolar Macrophages in Patients with COPD and in a Mouse Model

• DOI: 10.1126/scitranslmed.3002042
• Publication Date: 2011-04-13T18:24:52Z
• Authors: Christopher J. Ha...; Rajesh K. Thimmul...; Sanjay Sethi; Xiaoni Kong; Lonny Yarmus; Robert H. Brown; David Feller-Kopman; Robert Wise; Shyam Biswal
• Keywords: Male; 0301 basic medicine; NF-E2-Related Factor 2; Middle Aged; Haemophilus influenzae; 3. Good health; Mice; Pulmonary Disease, Chronic Obstructive; 03 medical and health sciences; Phagocytosis; Isothiocyanates; Sulfoxides; Macrophages, Alveolar; Pseudomonas aeruginosa; Animals; Humans; Female; Receptors, Immunologic; Cells, Cultured; Thiocyanates; Aged

Bacterial clearance in macrophages from lungs with chronic obstructive pulmonary disease is improved by stimulating the Nrf2 antioxidant signaling pathway.