Immune and Genetic Correlates of Vaccine Protection Against Mucosal Infection by SIV in Monkeys

• DOI: 10.1126/scitranslmed.3002351
• Publication Date: 2011-05-04T18:46:28Z
• Authors: Norman L. Letvin; Srinivas S. Rao; David C. Montefiori; Michael S. Seaman; Yue Sun; So-Yon Lim; Wendy W. Yeh; Mohammed Asmal; Rebecca S. Gelman; Ling Shen; James B. Whitney; Cathal Seoighe; Miguel Lacerda; Sheila Keating; Philip J. Norris; Michael G. Hudgens; Peter B. Gilbert; Adam P. Buzby; Linh V. Mach; Jinrong Zhang; Harikrishnan Bala...; George M. Shaw; Stephen D. Schmidt; John-Paul Todd; Alan Dodson; John R. Mascola; Gary J. Nabel
• Keywords: CD4-Positive T-Lymphocytes; 0301 basic medicine; immunodeficiency-virus type-1; 0303 health sciences; Mucous Membrane; prevent hiv-1 infection; rhesus-monkeys; Haplorhini; CD8-Positive T-Lymphocytes; trial; 3. Good health; thailand; 03 medical and health sciences; challenge; Animals; Humans; antibodies; Simian Immunodeficiency Virus; double-blind; Carrier Proteins; step; Alleles

A vaccine protecting monkeys against mucosal infection by simian immunodeficiency virus sheds light on immune and genetic correlates of protection.