Identification of a Disease-Defining Gene Fusion in Epithelioid Hemangioendothelioma

• DOI: 10.1126/scitranslmed.3002409
• Publication Date: 2011-09-01T13:09:13Z
• Authors: Munir R. Tanas; Andrea Sboner; Andre M. Oliveira; Michele R. Ericks...; Jessica Hespelt; Philip J. Hanwright; John Flanagan; Yuling Luo; Kerry Fenwick; Rachael Natrajan; Costas Mitsopoulos; Marketa Zvelebil; Benjamin L. Hoch; Sharon W. Weiss; Maria Debiec-Rychter; Raf Sciot; Rob B. West; Alexander J. Lazar; Alan Ashworth; Jorge S. Reis-Filho; Christopher J. Lord; Mark B. Gerstein; Mark A. Rubin; Brian P. Rubin
• Keywords: Genome, Human; Gene Expression Profiling; Calcium-Binding Proteins; Intracellular Signaling Peptides and Proteins; Chromosome Breakage; Immunohistochemistry; Polymerase Chain Reaction; Transcriptional Coactivator with PDZ-Binding Motif Proteins; Cytogenetic Analysis; Trans-Activators; Hemangioendothelioma, Epithelioid; Humans; Gene Fusion; In Situ Hybridization, Fluorescence; Transcription Factors

A newly identified gene fusion defines the vascular cancer epithelioid hemangioendothelioma and encodes a chimeric transcription factor.